Phenibut, kava extracts, and blue lotus products are marketed for sleep, calm, mood, or relaxation while carrying real risks for dependence, poisoning, impairment, and drug interactions.
Phenibut is not a lawful dietary ingredient in supplements and has been linked to sedation, respiratory depression, withdrawal, psychosis, coma, and death. Kava products have been associated with rare but serious liver injury. Blue lotus products may cause psychoactive effects and have been flagged by military safety resources because some products may be adulterated with synthetic cannabinoids.
These substances may appear in shots, capsules, gummies, vapes, powders, tinctures, or bottled drinks. The concern is not traditional plant use in every setting. The concern is modern retail products with concentrated ingredients, unclear dosing, undisclosed combinations, and inadequate safety warnings.
Phenibut exposure calls were reported to U.S. poison centers from 2009 through 2019.
Of reported phenibut exposures resulted in major effects, meaning life-threatening or disabling outcomes.
FDA says phenibut does not meet the definition of a dietary ingredient for supplements.